Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models
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چکیده
منابع مشابه
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models.
OBJECTIVE Conventional anticonvulsants reduce neuronal excitability through effects on ion channels and synaptic function. Anticonvulsant mechanisms of the ketogenic diet remain incompletely understood. Because carbohydrates are restricted in patients on the ketogenic diet, we evaluated the effects of limiting carbohydrate availability by reducing glycolysis using the glycolytic inhibitor 2-deo...
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PURPOSE 2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment with 2-DG can promote seizure susceptibility by assessing its effects on seizure threshold. For compar...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2009
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.21603